Cancer Bioengineering, Traumatic Brain Injury, Soft Materials, and More
Lab Overview
Lab Members
Research
Publications
Diversity and Inclusion
Open Positions
Engineering the Cell
Contact
More
Force-responsive networks
2024 ACS In Focus
Framework for Department-level Accountability to Diversify Engineering
Nature Reviews Bioengineering 2024
Needle-induced cavitation: A method to probe the local mechanics of brain tissue
Journal of the Mechanical Behavior of Biomedical Materials
Outlook and opportunities for engineered environments of breast cancer dormancy
Science Advances 2024
Synthetic Living Materials in Cancer Biology
Acute and Chronic Neural and Glial Response to Mild Traumatic Brain Injury in the Hippocampus
Biophysical Journal 2024
Molecularly Shielded, On-Demand, Ultrasound-Cured Polymer Networks
Macromolecules 2024
Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation
Cell Systems 2023
Challenges and opportunities modeling the dynamic tumor matrisome
Biomedical Engineering Frontiers 2023
Live cell lineage tracing of dormant cancer cells
Advanced Healthcare Materials 2023
Tenascin-C activation of lung fibroblasts in a 3D synthetic lung extracellular matrix mimic
Advanced Materials 2023
Equitable hiring strategies towards a diversified faculty
Nature Biomedical Engineering 2023
Strain-stiffening hydrogels with dynamic, secondary cross-linking
Langmuir 2023
Roadmap on biomaterials for women's health
Journal of Physics Materials 2023
A synthetic, three-dimensional bone marrow hydrogel
Biomaterials 2022
Cavitation induced fracture of intact brain tissue
Biophysical Journal 2022
Systems approaches to uncovering the contribution of environment-mediated drug resistance
Current Opinion in Solid State and Materials Science 2022
Agent-Based Models Help Interpret Patterns of Clinical Drug Resistance by Contextualizing Competition Between Distinct Drug Failure Modes
Cellular and Molecular Bioengineering 2022
Materials-driven approaches to understand extrinsic drug resistance in cancer
Soft Matter 2022
Genetic Mutations Associated with Hormone-Positive Breast Cancer in a Small Cohort of Ethiopian Women
Annals of Biomedical Engineering 2021
Localized characterization of brain tissue mechanical properties by needle induced cavitation rheology and volume controlled cavity expansion
Journal of the Mechanical Behavior of Biomedical Materials 2021
Cavitation in soft matter
PNAS 2020
Seeded laser-induced cavitation for studying high-strain-rate irreversible deformation of soft materials
Soft Matter 2020
The 2020 Young Innovators of Cellular and Molecular Bioengineering
Cellular and Molecular Bioengineering 2020
Control of Astrocyte Quiescence and Activation in a Synthetic Brain Hydrogel
Advanced Healthcare Materials 2020
Differentiation of Pathogenic Th17 Cells is Negatively Regulated by Let-7 MicroRNAs in a Mouse Model of Multiple Sclerosis
Frontiers in Immunology 2020
Emerging concepts and tools in cell mechanomemory
Annals of Biomedical Engineering 2020
Tumor cell-organized fibronectin is required to maintain a dormant breast cancer population
Science Advances 2020
OrgDyn: feature- and model-based characterization of spatial and temporal organoid dynamics
Bioinformatics 2020
Vascularized biomaterials to study cancer metastasis
An omentum-inspired 3D PEG hydrogel for identifying ECM drivers of drug resistant ovarian cancer
APL Bioengineering 2019
Applicability of drug response metrics for cancer studies using biomaterials
Philosophical Transactions of the Royal Society B 2019
Biomechanical microenvironment regulates fusogenicity of breast cancer cells
ACS Biomaterials and Bioengineering 2019
2D or 3D? How in vitro cell motility is conserved across dimensions, and predicts in vivo invasion
Bioengineering & Translational Medicine 2019
Implantable pre-metastatic niches for the study of microenvironmental regulation of disseminated human tumour cells
Nature Biomedical Engineering 2018
Tumor‐stroma interactions differentially alter drug sensitivity based on the origin of stromal cells
Molecular Systems Biology 2018
Complementary, semiautomated methods for creating multidimensional PEG-based biomaterials
ACS Biomaterials Science and Engineering 2018
Zwitterionic PEG-PC hydrogels modulate the foreign body response in a modulus-dependent manner
Biomacromolecules 2018
Acetyl-CoA promotes glioblastoma cell adhesion and migration through Ca2+–NFAT signaling
Genes and Development 2018
Comparative Study of Multicellular Tumor Spheroid Formation Methods and Implications for Drug Screening
Control of Thiol-Maleimide Reaction Kinetics in PEG Hydrogel Networks
Acta Biomaterialia 2018
Mechanosensing of Integrin 6 and EGFR Converges at Calpain 2
Biomaterials 2018
Anomalous diffusion as a descriptive model of cell migration
APL Bioengineering 2018
Cross-platform mechanical characterization of lung tissue
PLoS One 2018
A Student-Created, Open Access, Living Textbook
Chemical Engineering Education 2017
Strain-stiffening gels based on latent crosslinking
Soft Matter 2017
A Biomaterial Screening Approach to Reveal Microenvironmental Mechanisms of Drug Resistance
Integrative Biology 2017
Differential cathepsin responses to inhibitor-induced feedback: E-64 and cystatin C elevate active cathepsin S and suppress active cathepsin L in breast cancer cells
The International Journal of Biochemistry & Cell Biology 2016
Biochemical and biomechanical drivers of cancer cell metastasis, drug response and nanomedicine
Drug Discovery Today 2016
The predictive link between matrix and metastasis
Current Opinion in Chemical Engineering 2016
Mechanics of intact bone marrow
Fewer bacteria adhere to softer hydrogels
ACS Applied Materials and Interfaces 2015
A cell-ECM screening method to predict breast cancer metastasis
Integrative Biology 2015
Thermal-responsive behavior of a cell compatible chitosan:pectin hydrogel
Biomacromolecules 2015
Smooth muscle stiffness sensitivity is driven by soluble and insoluble ECM chemistry
Cellular and Molecular Bioengineering 2015
Promoting cell adhesion on slippery phosphorylcholine hydrogel surfaces
J Materials Chemistry B 2014
Sorafenib resistance and JNK signaling in carcinoma during extracellular matrix stiffening
Biomaterials 2014
A heparin decamer bridges a growth factor and an oligolysine by different charge-driven interactions
Biomacromolecules 2013
PEG-Phosphorylcholine hydrogels as tunable and versatile platforms for mechanobiology
Bio-inspired materials for parsing matrix physicochemical control of cell migration
Integrative Biology 2012
Autocrine-controlled formation and function of tissue-like aggregates by primary hepatocytes in micropatterned hydrogel arrays
Tissue Engineering Part A 2011
Marrow-derived stem cell motility in 3D synthetic scaffold is governed by geometry along with adhesivity and stiffness
Biotechnology and Bioengineering 2011
The influence of ascorbic acid, TGF-1, and cell-mediated remodeling on the bulk mechanical properties of 3-D PEG-fibrinogen constructs
Biomaterials 2009
ECM compliance regulates osteogenesis by influencing MAPK signaling downstream of RhoA and ROCK
Journal of Bone and Mineral Research 2009
The effects of matrix stiffness and RhoA on the phenotypic plasticity of smooth muscle cells in a 3-D biosynthetic hydrogel system
Biomaterials 2008
A novel 3-D model to quantify metastatic melanoma invasion
Molecular Cancer Therapeutics 2007
The regulation of osteogenesis by ECM rigidity in MC3T3-E1 cells requires MAPK activation
Journal of Cellular Physiology 2007
The emergence of ECM mechanics and cytoskeletal tension as important regulators of cell function
Cell Biochemistry and Biophysics 2007